Sydney M. Shaffer

Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance

Abstract SETD2 is a critical tumor suppressor in lung cancer that catalyzes histone H3 lysine 36 (H3K36) trimethylation. Oncogenic histone H3 alleles, including H3 K36M , causally drive cancer formation by dominantly inhibiting SETD2 and other H3K36 methyltransferases. Here we sh...