Swastik Singh

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket

Frailty is increasingly recognized as a clinically relevant measure of biological aging, yet comparable assessment tools are lacking for scalable invertebrate models. Here, we introduce a Composite Frailty Index (CFI) for the house cricket ( Acheta domesticus ) integrating automa...

The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets

Abstract The house cricket ( Acheta domesticus ) is a promising preclinical geroscience model due to its short lifespan, low maintenance, age-associated functional decline, and responsiveness to geroprotective drugs. Continuous dosing with rapamycin, acarbose, and phenylbutyrate...