Sung Jae Shin

Type I IFN-induced viperin promotes Mycobacterium tuberculosis survival by suppressing the protective COX-2/PGE2/IL-1β axis in macrophages

Type I interferon (IFN) signaling is associated with detrimental outcomes during Mycobacterium tuberculosis (Mtb) infection, in part through antagonism of IL-1β-mediated protective immunity. Viperin, an IFN-stimulated gene induced downstream of type I IFN, has previously been imp...