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Zingiberis Rhizoma Ethanol Extract Attenuates Recognition Memory Deficits and Neuroinflammation in a Mouse Model of Bilateral Common Carotid Artery Stenosis

Chronic cerebral hypoperfusion (CCH), a key contributor to vascular dementia (VaD), causes white matter injury and neuroinflammation. We evaluated the neuroprotective effects of 6-gingerol-rich Zingiberis Rhizoma ethanol extract (ZRex) in a mouse bilateral common carotid artery s...

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited. Natu...