Sui Seng Tee

Cirrhosis severity modulates proteomic and immune landscapes in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) most often arises in cirrhotic livers, yet the biological impact of cirrhosis severity on the tumor proteome remains poorly understood. Here, we performed a comprehensive quantitative proteomic analysis of 141 HCC tumors stratified by the d...