Stuart McIntosh

Individual-level health inequalities in breast cancer stage and survival in Northern Ireland: a population-based cohort study

Abstract Background Understanding the impact of health inequalities on breast cancer presentation, treatment and survival is important. This study investigated individual-level health inequalities on stage at diagnosis and mortality. Methods Women newly diagnosed with breast canc...

A randomized controlled trial of CDK7 inhibitor samuraciclib plus fulvestrant in advanced HR+/HER2− breast cancer

Abstract Resistance to CDK4/6 inhibitors remains a major challenge in HR+/HER2− metastatic breast cancer. Samuraciclib is an oral selective CDK7 inhibitor that may overcome resistance to CDK4/6 inhibitors, targeting transcriptional programs sustaining tumor growth. This study pre...