Stuart A.C. McDonald

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

Barrett's oesophagus is the metaplastic precursor to oesophageal adenocarcinoma; it is initiated by exposure of the squamous oesophageal epithelium to acid reflux. Wound repair mechanisms lead to the migration of columnar cells into the denuded lower oesophageal niche. These colu...