Stijn Keereweer

Distinct epigenetic signatures define HPV-positive and HPV-negative tonsil carcinomas

Introduction Epigenetic modifications, particularly DNA methylation, play a key role in oropharyngeal squamous cell carcinoma (OPSCC). This is the first study to apply genome-wide methylated DNA sequencing (MeD-seq) to identify differentially methylated regions (DMRs) in OPSCC. B...