Steven Jacobson

ERVmancer: a phylogeny-guided framework for decoding human endogenous retrovirus regulatory mechanisms in health and disease

Human endogenous retroviruses (HERVs), remnants of ancient infections, comprise approximately 8% of the human genome and influence development, immunity, and cancer. Their repetitive sequences complicate short-read analysis because reads often cannot be assigned to individual loc...

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

ABSTRACT Objective Susac syndrome (SS) is a rare CD8 + T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteom...