Steven G. Van Lanen

The Endogenous Metabolite Hypochlorite Activates Indoleamine 2,3‐Dioxygenase‐1 for Catalysis: Functional and Mechanistic Implications

ABSTRACT Indolamine 2,3‐dioxygenase (IDO1) catalyzes the oxidative cleavage of l ‐tryptophan ( l ‐Trp) to N′ ‐formyl‐ l ‐kynurenine ( l ‐NFK). The generally used in vitro assay for probing IDO1 activity relies on ascorbic acid and synthetic methylene blue to initiate the reaction...