Stephen P. Argent

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...