Stephen Orena

Temporal organization of the Plasmodium falciparum transcriptome prioritises genetic polymorphisms associated with artemisinin response

Abstract Artemisinin-based combination therapies (ACTs) have substantially reduced the global burden of malaria, but the emergence and spread of artemisinin partial resistance (ART-R) threatens these gains. Although mutations in Plasmodium falciparum kelch13 (pfk13) are establish...