Stephen L. Tilley

Iron, Tuberculosis, and Particle-Related Exposures Including Smoking

The availability of iron controls the abundance and diversity of life. Microbial pathways for iron acquisition account for their replication and virulence. The balance of interactions defining a microbial community can be altered by environmental stress. Decreased iron availabili...

T cell–intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models

Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role rem...