Stephen B. Baylin

Cryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase

Abstract ZNFX1 is an RNA helicase that plays a critical role in host defense against viral infections. Recent studies further revealed that ZNFX1 harbors an unexpected RNA-ubiquitinating E3 ligase activity, raising fundamental questions about how RNA-binding activates this multif...