Stéphanie Le Hellard

Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk

Abstract Background Season at birth has been associated with increased risk for psychotic disorders. Epigenetic markers, which can be influenced by environmental exposures, may help to understand the mechanisms of seasonal effects. Aims To investigate two types of seasonal influe...

65. HIGHER POLY-METHYLATION SCORE FOR SCHIZOPHRENIA IS ASSOCIATED WITH GREATER NEGATIVE SYMPTOM SEVERITY AT 10-YEAR FOLLOW-UP

Background Negative symptoms are among the most disabling features of psychotic disorders and frequently persist over time. Baseline clinical measures (e.g. symptom severity at illness onset) explain only part of the variability in long-term outcomes, highlighting the need for im...