Štěpán Timr

Poised for Allostery: Specific Interactions Underlie Precise Positioning of the C-Terminal Tail in Phosphofructokinase-1

Abstract Disordered terminal segments often regulate enzymes, but how such flexible elements achieve the spatial precision required for allostery remains poorly understood. Using human phosphofructokinase-1 as a model system, we combine enhanced-sampling molecular dynamics simula...