Stelios T. Andreadis

Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells

Salivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result in undesirable side effects. To address this issue, we’ve developed a developmentally inspired stra...

Innate immune cell-mediated regeneration of acellular vascular grafts in aged hosts

Previously we reported on engineering cell-free vascular grafts that harnessed the potential of the innate immune system to remain patent and regenerate into functional neo-arteries in small and large, preclinical animal models. However, the performance of these grafts in aged ho...