Stefano Navarro

When platelets are under pressure: an angiotensin II-TGF-β axis in hypertensive patients leads to receptor PAR4 overexpression

Angiotensin II-TGF-β1-Smad2 signalling promotes PAR4 overexpression and platelet priming in hypertension. The schematic depicts the proposed mechanism by which an angiotensin II-high hypertensive phenotype drives megakaryocyte reprogramming and platelet hyperreactivity. In normos...