Stefan Rakete

Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5

BACKGROUND: Primary aldosteronism is frequently caused by mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding a G-protein inwardly rectifying potassium channel. These mutations disrupt the channel’s selectivity filter, permitting abn...