Stefan Bröer

Structure-guided targeting of the LAT1-4F2hc amino acid transporter in cancer and brain disorders

Abstract The heterodimeric amino acid transporter L-type amino acid transporter 1 (LAT1)-4F2hc (SLC7A5-SLC3A2) is a key regulator of large neutral amino acid exchange, linking extracellular nutrient availability to intracellular growth signaling. It is physiologically enriched at...