Stanislav Avdieiev

In vivo Tracking of Clonal Dynamics in UV-Induced Skin Carcinogenesis Reveals Tumor Development from Goliath Clades

Abstract While the genetic paradigm of cancer is powerful, it remains incomplete. For example, high mutational burdens are commonplace in homeostatically-stable epithelia, but the presence of driver mutations alone does not result in cancer. Here, we revealed additional factors c...

Density dependence and evolvability limit adaptive therapy in non-small cell lung cancer mouse model

Abstract Using NSG mice grafted with H3122 non-small cell lung cancer cells, we compared outcomes from (1) continuous therapy with alectinib, (2) adaptive therapy where alectinib was cycled on and off based on a mouse’s tumor burden, and (3) no treatment. Adaptive therapy has pro...