SRISTI NANDA

Non-canonical pore architecture underlies constitutive gating of human retinal TRPM1

Transient receptor potential melastatin 1 (TRPM1), a Ca²⁺-permeable nonselective cation channel essential for retinal ON bipolar cell signaling and night vision, and implicated in congenital night blindness, has remained structurally and functionally poorly characterized. Here we...