Søren R. Paludan

A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway

Type I interferons (IFNs) are induced by pattern recognition receptors (PRRs) of the innate immune system to protect against foreign pathogens and malignant transformation, and their production must be tightly regulated to balance antiviral defense with tissue homeostasis. To def...