Song Ye

Enantioselective Synthesis of Axially Chiral Tetraphenylethenes via NHC-Catalyzed Desymmetrization and Following Kinetic Resolution

Abstract Herein, we report an efficient method for the enantioselective construction of axially chiral tetraphenylethylene (TPE) via N-heterocyclic carbene (NHC)-catalyzed desymmetrization of prochiral isophthalaldehyde-derived TPEs. Both aliphatic alcohols and phenols were well-...