Song Li

Glycosaminoglycan-Based CD44-Targeted Nanoparticles for Cancer Therapy: Biological Barriers and Barrier-Informed Design Strategies

Abstract Nanoparticle (NP)-based drug delivery has been explored to improve the therapeutic index of anticancer agents by enhancing tumor accumulation and reducing systemic toxicity. Among active targeting approaches, cluster of differentiation 44 (CD44) has attracted attention b...

Desulfinylation of the deubiquitinase USP7 by SRXN1 attenuates oxidative acute liver injury

Protein S -sulfinylation is a reversible oxidative cysteine modification, but its contribution to acute liver injury such as those induced by acetaminophen (APAP) overdose has not been reported. Sulfiredoxin-1 (SRXN1) is the only oxidoreductase known to reduce the sulfinylated pr...