Somponnat Sampattavanich

Advances in Organoid Technology: Bridging the Gap Between Research and Therapy

Organoids Are Us is a symposium series that provides a snapshot in time of the latest and emerging developments in organoid technology [...]

Perivascular immune organization and spatial architecture are associated with immunotherapy response in non-small cell lung cancer

Clinical responses to immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) remain highly heterogeneous and PD-L1 expression alone has limited predictive performance. Emerging evidence suggests that therapeutic response depends not only on immune cell abundanc...

PARP inhibition induces a redox-dependent dormant reservoir vulnerable to disulfiram in high-grade serous ovarian cancer

Resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in high-grade serous ovarian cancer (HGSOC) is increasingly driven by non-genetic drug-tolerant dormant cell populations, yet the adaptive programs sustaining these cells remain poorly understood. Here, we established a...