Somenath Sen

XIST Self-regulates its association with THOC2 and the nuclear epigenetic machinery via miR-186 in Alzheimer’s disease

Alzheimer’s disease (AD) exhibits a strong female bias, yet the underlying molecular basis remains poorly understood. This study identifies the long non-coding RNA (lncRNA) XIST, the key mediator of X-chromosome inactivation (XCI), as a regulator of female-specific AD pathology....