Sofia Lykidis

uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast

Abstract Cyclin-dependent kinases (Cdks) require activating T-loop phosphorylation, a modification considered constitutive. Here, we examine the regulation of the Cdk-activating kinase, Cak1, in budding yeast. We measure Cak1 levels and the activating T169 phosphorylation of Cdc2...