Smita Jain

The Substrate-EngineModel of Ferroptosis: Stage-SpecificTargeting of Acyl-CoA Synthetase Long-Chain Family Member 4 and 5-Lipoxygenasein Alzheimer’s Disease

Abstract Ferroptosis-targeted therapies in Alzheimer’s disease (AD) have yielded consistent preclinical evidence; however, their translation into clinical outcomes has remained elusive. This mismatch reflects a fundamental flaw that conceptualizes this peroxidative pathway as a s...