Siyi Xu

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

ABSTRACT The stimulator of interferon genes (STING) pathway represents a central component of innate anti‐tumor immunity; however, the efficacy of STING‐targeted therapies is frequently limited by tumor‐intrinsic resistance mechanisms. Here, we identify lactate‐driven lactylation...

Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex

Understanding how cellular architecture organizes cortical function requires mesoscopic approaches that resolve structure-function coupling in vivo. Here we introduce cerebral blood flow (CBF) and cell-body staining intensity (CSI) similarity index (CCSI), a localized similarity...