Siyi Chen

DFGLM-TCM: an integrated knowledge-and experience-driven large language model system for Traditional Chinese Medicine practice

Abstract Traditional Chinese Medicine (TCM) clinical practice depends on both codified theoretical knowledge and practitioner-specific experience, which differ in their data sources, reasoning patterns, and scope of generalization. We developed DFGLM-TCM, a modular large language...

p21 Inhibition Rescues Radiation‐Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb–Smad2/3–Runx2 Axis

ABSTRACT Background Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation‐induced DNA damage, but its role in ORNJ remains unknown. Methods An ORNJ mouse model was established. Single‐cell...