Sittinan Chanarat

The KH-like CTD of Prp5 is conserved and essential for splicing

Pre-mRNA splicing is a fundamental process in eukaryotic gene expression. The RNA helicase Prp5 bridges U1 and U2 snRNPs during spliceosome assembly and enhances splicing fidelity. While the N-terminal domain (NTD) of Prp5 is well characterized, the C-terminal domain (CTD) remain...