Siqi Wang

Cu-Catalyzed Cross-Coupling of (Hetero)Aryl Halides with Malonates: One-Pot Assembly of α-Arylacetic Acid Scaffolds

Abstract A direct synthesis of α-arylacetic acids from (hetero)aryl chlorides and bromides and malonates via Cu/oxalamide-catalyzed cross-coupling with tandem hydrolysis and decarboxylation is described. Enabled by tailored oxalamide ligand L4, the reaction proceeds smoothly unde...