Simone Sidoli

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent...

Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance

Abstract SETD2 is a critical tumor suppressor in lung cancer that catalyzes histone H3 lysine 36 (H3K36) trimethylation. Oncogenic histone H3 alleles, including H3 K36M , causally drive cancer formation by dominantly inhibiting SETD2 and other H3K36 methyltransferases. Here we sh...