Simona Paladino

HIPK2 loss promotes TDP-43 cytoplasmic mis-localization through MAPK-pathway and is associated with TDP-43 proteinopathy in vivo

Abstract Homeodomain Interacting Protein Kinase 2 (HIPK2) is a stress sensor kinase that has emerged as a key regulator of neuronal homeostasis and survival. In this study, we investigated the role of HIPK2 in neurodegeneration using both in vivo and in vitro models. We show that...