Simona Mrakic‐Sposta

Differential homeostatic reorganization during high-altitude trekking: multisystemic adaptations and organ-specific resilience

Abstract Introduction High-altitude exposure combined with physical activity triggers complex systemic adaptations. However, multidisciplinary longitudinal investigations into these multiorgan responses remain limited. This prospective observational study aimed to investigate the...

Probiotic supplementation preserves oxygen saturation during severe hypobaric hypoxia in lowland and high-altitude populations

Hypobaric hypoxia (HH) reduces SpO₂, impairing acclimatization and performance. The multi-strain probiotic Oxxyslab enhance oxygen availability and aid hypoxia acclimatization by reducing intestinal oxygen consumption through HIF-1α modulation. We performed a randomized, double-b...