Si‐Ming Yuan

Advances in the Targeted Therapy for PIK3CA‐Related Overgrowth Spectrum (PROS): From Molecular Mechanisms to Clinical Translation

The PIK3CA-related overgrowth spectrum (PROS) encompasses a group of rare, somatic disorders caused by somatic activating mutations in PIK3CA, resulting in a dysregulated PI3K/AKT/mTOR pathway and consequent segmental tissue overgrowth and vascular malformations affecting multipl...