Siming Huang

Rigid-Flexible Coupling Pore Engineering in Covalent Organic Frameworks Enables the Selective Identification of Nucleotide Analogues

Abstract Covalent organic frameworks (COFs) offer programmable pore architectures and tunable host–guest interactions, yet their rigid channels limit the selective recognition of structurally similar biomolecules─a longstanding challenge in sensor design. Inspired by enzymatic po...

Mechanochemical Encapsulation of Enzymes in a Highly Hydrophilic HOF: Harnessing Pore Microenvironment for Enhanced Biocatalysis

ABSTRACT Enzymes immobilized within hydrogen‐bonded organic frameworks (HOFs) often suffer from reduced catalytic activity due to mass transfer limitations and pore channel blocking by residual organic solvents from conventional solution‐phase synthesis. In addition, the correlat...