Silva Ricardo

New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence

Abstract p53 is, without a doubt, one of the most powerful genes in our genome, as it makes growth vs arrest, repair vs replacement, catabolism vs anabolism, life vs death decisions in the cell. An alteration or malfunction in p53 may lead to cancer, degeneration or premature age...