Sile Hu

Hoxc13 polyglycine repeat gain-of-function contributes to mammalian integument evolution by altering targeted genes and interactions

Abstract Background Hoxc13 is a critical transcription factor that regulates the expression of hair keratin genes. Our previous study showed that during mammalian evolution, the Hoxc13 protein acquired a characteristic polyglycine repeat (polyG) insertion. This insertion distingu...