Author
Sidário Rodrigues Malheiros-junior
Recent research
- Health & MedicineOpen access
This focused review examines the current evidence linking neurological symptoms during tirzepatide treatment to metabolic and fluid-electrolyte disturbances. Evidence from regulatory documents, randomised trials, human physiology, pharmacovigilance analyses, and case reports is s...
- Health & MedicineOpen access
This focused review examines the current evidence linking neurological symptoms during tirzepatide treatment to metabolic and fluid-electrolyte disturbances. Evidence from regulatory documents, randomised trials, human physiology, pharmacovigilance analyses, and case reports is s...
- BiologyOpen access
This revised theoretical and computational study examines whether energetic cost constitutes a fundamental constraint on the evolutionary accessibility of G protein-coupled receptor (GPCR)-class signalling in unicellular systems. Using explicit residue-based energetic accounting,...
- Society & EconomicsOpen access
No Zombie Can Ask the Phenomenal Question: Self-Exclusion and the Limits of Metaphysical Inference
This conceptual article examines a neglected asymmetry in the philosophical-zombie thought experiment. A Chalmersian zombie, being physically and functionally identical to a conscious person, can produce the same verbal questions, reports, and judgments about consciousness. The p...
- BiologyOpen access
No Zombie Can Ask the Phenomenal Question: Self-Exclusion and the Limits of Metaphysical Inference
This conceptual article examines a neglected asymmetry in the philosophical-zombie thought experiment. A Chalmersian zombie, being physically and functionally identical to a conscious person, can produce the same verbal questions, reports, and judgments about consciousness. The p...
- Health & MedicineOpen access
This record contains the preprint and supporting materials for a prospectively registered systematic review evaluating whether astrocytic or lipid-handling biomarkers precede phosphorylated tau (p-tau) in populations at genetic risk for Alzheimer’s disease. The review was registe...
- Health & MedicineOpen access
Autosomal dominant and sporadic Alzheimer’s disease converge on an almost indistinguishable phenotype despite radically different genomic origins, and carriers of high-risk variants exist who never develop clinical disease. Both observations point to a second necessary event beyo...
- BiologyOpen access
Hierarchical Functional Shedding (HFS) is a connectivity-maintenance hypothesis developed to explain why higher-order cognitive integration may deteriorate while wakefulness, elementary perception, recognition, and overlearned behaviour remain comparatively preserved. The model p...
- BiologyOpen access
This theoretical study develops the Connectivity Maintenance Cost (CMC) framework by modelling how biological and neural networks lose functional integration when the resources available for connectivity maintenance fall below critical thresholds. Rather than treating energetic e...
- BiologyOpen access
Hierarchical Functional Shedding (HFS) is a connectivity-maintenance hypothesis developed to explain why higher-order cognitive integration may deteriorate while wakefulness, elementary perception, recognition, and overlearned behaviour remain comparatively preserved. The model p...
- BiologyOpen access
This theoretical study develops the Connectivity Maintenance Cost (CMC) framework by modelling how biological and neural networks lose functional integration when the resources available for connectivity maintenance fall below critical thresholds. Rather than treating energetic e...
- Health & MedicineOpen access
In the pivotal tirzepatide clamp study the acute glucagon response was preserved, but absolute glucagon concentrations were lower at every plateau except the nadir; catecholamine responses at the 63 mg/dL alerting threshold were approximately 70% lower, converging with placebo at...
- Health & MedicineOpen access
In the pivotal tirzepatide clamp study the acute glucagon response was preserved, but absolute glucagon concentrations were lower at every plateau except the nadir; catecholamine responses at the 63 mg/dL alerting threshold were approximately 70% lower, converging with placebo at...
- BiologyOpen access
A widely held intuition in evolutionary cell biology holds that complex signalling machinery is excluded from unicellular organisms by energetic expense. This paper tests that intuition on a well-posed case and finds it false. Explicit bioenergetic accounting places a complete G-...
- Society & EconomicsOpen access
No Zombie Can Ask: The Self-Excluding Question and the Symmetry of Unanswerability
The zombie argument treats the unanswerability of “why is there experience?” as evidence against physicalism. This paper grants conceivability and poses the inverse question — given that experience exists and is metabolically expensive, what would have made it necessary? — showin...
- Society & EconomicsOpen access
No Zombie Can Ask: The Self-Excluding Question and the Symmetry of Unanswerability
The zombie argument treats the unanswerability of “why is there experience?” as evidence against physicalism. This paper grants conceivability and poses the inverse question — given that experience exists and is metabolically expensive, what would have made it necessary? — showin...