Sidário Rodrigues Malheiros-junior

Hypoglycaemia during incretin receptor agonist therapy in people without diabetes: beyond acute counterregulation

In the pivotal tirzepatide clamp study the acute glucagon response was preserved, but absolute glucagon concentrations were lower at every plateau except the nadir; catecholamine responses at the 63 mg/dL alerting threshold were approximately 70% lower, converging with placebo at...

Hypoglycaemia during incretin receptor agonist therapy in people without diabetes: beyond acute counterregulation

In the pivotal tirzepatide clamp study the acute glucagon response was preserved, but absolute glucagon concentrations were lower at every plateau except the nadir; catecholamine responses at the 63 mg/dL alerting threshold were approximately 70% lower, converging with placebo at...

Hypoglycaemia during incretin receptor agonist therapy in people without diabetes: beyond acute counterregulation

In the pivotal tirzepatide clamp study the acute glucagon response was preserved, but absolute glucagon concentrations were lower at every plateau except the nadir; catecholamine responses at the 63 mg/dL alerting threshold were approximately 70% lower, converging with placebo at...

The Cost Is Not the Constraint: A Drift-Barrier Analysis of GPCR-Class Signalling in Unicellular Systems

A widely held intuition in evolutionary cell biology holds that complex signalling machinery is excluded from unicellular organisms by energetic expense. This paper tests that intuition on a well-posed case and finds it false. Explicit bioenergetic accounting places a complete G-...

Connectivity Maintenance Cost II: A Thermodynamic Reconstruction from a Single Primitive

Functions are partitioned by duty cycle. A function whose state cannot be reconstructed from instantaneous sensory input must be maintained continuously and is limited by instantaneous flux; a function that can be recomputed on demand may defer consumption and is limited by integ...

No Zombie Can Ask: The Self-Excluding Question and the Symmetry of Unanswerability

The zombie argument treats the unanswerability of “why is there experience?” as evidence against physicalism. This paper grants conceivability and poses the inverse question — given that experience exists and is metabolically expensive, what would have made it necessary? — showin...

No Zombie Can Ask: The Self-Excluding Question and the Symmetry of Unanswerability

The zombie argument treats the unanswerability of “why is there experience?” as evidence against physicalism. This paper grants conceivability and poses the inverse question — given that experience exists and is metabolically expensive, what would have made it necessary? — showin...

No Zombie Can Ask: The Self-Excluding Question and the Symmetry of Unanswerability

The zombie argument treats the unanswerability of “why is there experience?” as evidence against physicalism. This paper grants conceivability and poses the inverse question — given that experience exists and is metabolically expensive, what would have made it necessary? — showin...