Sibei Liu

Molecular basis of PADI6 species-specific oligomerization in maternal regulatory complexes

Peptidyl arginine deiminase 6 (PADI6) is an essential maternal effector in mammalian oocytes and preimplantation embryos. Recently, we identified the conserved maternal PADI6-UHRF1-UBE2D complex (MPU). MPU, together with the subcortical maternal complex (SCMC), further forms the...