Siavash Vahidi

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site

ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by paradoxical activation...

Resolving Hidden Stoichiometriesin Bacterial ProteasomeActivator (Bpa)-Substrate Complexes by Cryo-EM and Charge DetectionMass Spectrometry

Abstract Bacterial proteasome activator (Bpa) is a regulatory particle within the Mycobacterium tuberculosis (Mtb) proteasome system that facilitates ATP-independent substrate engagement and delivery to the 20S core particle (CP) for degradation. The best characterized Bpa substr...