Sian Thistlethwaite

Expanding the BiocatalyticToolbox: A Singular P450Enzyme Efficiently Produces Diverse Pharmaceutical Metabolites

Abstract P450 BM3 is a natural fusion protein with a P450 domain fused to its necessary redox partner and capable of binding a range of fatty acids at high catalytic rates. The flexibility of the active site and catalytic efficiency have led to extensive research aimed at modifyi...