Shyni Varghese

Estrogen promotes tumor phenotypes in ER+ and ER– breast cancer through UGDH-GPR30

Estrogen can promote aggressive tumor phenotypes in estrogen receptor–positive (ER + ) breast cancer; however, ER – cell lines are not widely considered estrogen responsive. Noncanonical estrogen-stimulated pathways such as the membrane-bound G protein–coupled estrogen receptor (...