Shu‐Li You

Chiral Phosphoric Acid-Catalyzed Asymmetric Allylic Dearomatization of Tryptamines with Alkoxyallenes

Abstract Catalytic asymmetric dearomatization of tryptamines has emerged as a powerful strategy for constructing chiral pyrroloindoline frameworks, which are ubiquitous in bioactive natural products. Despite tremendous advances in transition-metal-catalyzed synthesis of allyl-sub...

Enantioselective Synthesis of Azahelicenes via Rh-Catalyzed C–H Functionalization of 6-Hydroxyisoquinoline Derivatives with Alkynes

Abstract Herein, we report an asymmetric C–H functionalization of 6-hydroxyisoquinoline derivatives and annulation with internal alkynes. The reaction is catalyzed by a chiral cyclopentadienyl (Cp)-Rh complex in combination with a modified chiral amino acid. A series of azahelice...

Intramolecular [4 + 2] Cycloaddition via Photoredox Dual Dearomatization of Indole and Furan Units

Abstract Despite significant advances in the field of dearomatization, dual dearomatization remains underdeveloped. Herein, we report an intramolecular dual dearomatization reaction of indoles and furans by photoredox catalysis. This method enables the construction of four fused...