Shujuan Liu

Defective PDZK1 palmitoylation impairs epididymosome-mediated cholesterol transport and contributes to asthenozoospermia

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, involves dysregulated cholesterol efflux during epididymal maturation, yet the underlying mechanisms remain elusive. Here, we demonstrate that PDZK1 protein level and its palmitoylati...

Engineering at surface-interface triggered by single sites to regulate selectivity of CO2 reduction

Rational catalyst design and reaction mechanism investigation guided by clarification of relationship between the active sites and elementary reaction steps at molecular level are challenging but essential in heterogeneous catalysis. Here we demonstrate the alteration of active s...