Shuangying Gui

CCR2-mediated chemotactic plant-derived extracellular vesicles for targeting and remodeling the immune microenvironment in cerebral ischemia-reperfusion injury treatment

The recruitment of peripheral immune cells into the brain and the subsequent formation of an inflammatory microenvironment are key drivers of cerebral ischemia-reperfusion injury (CIRI). Current nanosystem-based therapeutic strategies primarily target the brain parenchyma, yet of...

Bioactive polysaccharides from the industrial crop Platycodon grandiflorus restore intestinal barrier integrity and suppress bEVs-mediated pyroptosis: A functional component for respiratory health management

Platycodon grandiflorus is widely recognized as an industrial crop due to the high value of its bioactive polysaccharides (PGP). Despite its traditional use for pulmonary and gastrointestinal health, the underlying mechanisms remain poorly defined. This study investigated whether...