Shuai Qian

A Microneedle Platform Co-loaded with Eugenol, Chlorogenic Acid, and Allopurinol for In Vivo Modulation of Pathological Crystal Formation in Experimental Gouty Arthritis

Abstract Gouty arthritis arises from pathological deposition of monosodium urate (MSU) crystals, whose interactions with surrounding tissues initiate and amplify inflammation. Here, we developed a nanoengineered microneedle (MN) platform for localized modulation of pathological c...

Nonlinear Responses of Anaerobic Methane Oxidation to Water Table Drawdown in Peatlands

Abstract Anaerobic oxidation of methane (AOM) serves as a key methane (CH4) sink that attenuates methane emissions from peatlands. Climate change has induced widespread water table drawdown in peatlands, but the response of AOM to the water table depth (WTD) and the temperature s...

Temperature-Dependent Crystallization Pathways ofthe Curcumin-Magnolol Coamorphous System: A Mechanistic Study IntegratingThermodynamics and Kinetics

Abstract Coamorphous drug systems have received increasing interest owing to their potential to improve the solubility, dissolution, and bioavailability of insoluble drugs. However, coamorphous systems exist in a high-energy state, making them prone to crystallization into stable...

Spatiotemporally Controlled Double Self‐Emulsifying Microneedles for Co‐Delivery of Eugenol and Puerarin to Promote Healing and Tissue Regeneration of Infected Diabetic Wounds

Chronic infected diabetic foot ulcers (DFUs) pose a persistent challenge due to biofilm-shielded infections, excessive inflammation, and impaired tissue repair. Here, we present a first-in-class microneedle system that redefines eugenol (EUG), a natural compound, as a multifuncti...