Shota Higashihira

Halicin‑Rifampicin Combinations Are More Effective Than Monotherapy Against Biofilm‑Residing Staphylococcus Aureus and Prevent Emergence of Rifampicin Resistance

Background: Biofilms shield bacteria from immune defenses and antibiotics, contributing to implant-associated infections, particularly those caused by Staphylococcus aureus (S. aureus). Halicin, a repurposed antimicrobial with broad-spectrum activity, has shown promise against pl...